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Open access Aug 2026

1-Year follow-up evaluation of TAK-003 dengue vaccine effectiveness against symptomatic disease and hospitalisation in adolescents during the 2024–2025 outbreak in São Paulo, Brazil: a test-negative case-control study

Summary Background Dengue is a growing global health threat. Our initial evaluation of the TAK-003 dengue vaccine in adolescents during the 2024 outbreak in São Paulo State, Brazil, showed short-term protection but suggested possible effectiveness waning after 90-days of the first dose, and had limited power to estimat...

Lisany Krug Mareto, Thiago Sanches Brumatti, Roberto Dias de Oliveira et al. · 0 citations
Open access Aug 2026

Evaluating the influence of vaccine archetypes and epidemiological conditions on clinical trial metrics for tuberculosis vaccine candidates

While vaccines conferring leaky protection against infection and disease tested in settings with very high ARI could modestly underestimate efficacy, trials could be adequately powered with a fraction of the sample size in such settings.

J. Andrews, S. Hermans, Richard G. White et al. · 0 citations

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