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Open access Sep 2026

A global S-palmitoylation map of Trypanosoma cruzi identifies ABCA10 as a key component of a redundant heme-acquisition system

Survival and transmission of the human pathogen Trypanosoma cruzi depend on dynamic remodeling of its membrane proteome, yet the post-translational networks governing this plasticity remain obscure. Using metabolic labeling and quantitative mass spectrometry, we present a comprehensive map of the T. cruzi S-palmitoylom...

Gonzalo Seminario-Mondejar, M. Etheridge, Anthony A. Ruberto et al. · 0 citations
Open access Jul 2026

Functional Mapping of the Trypanosoma cruzi Serinome by Fluorophosphonate Activity-Based Protein Profiling

An activity-based chemoproteomic map of the T. cruzi epimastigote serinome is reported by combining genome-informed in silico curation with whole-cell activity-based protein profiling (ABPP) using a panel of cell-permeable fluorophosphonate (FP)-alkyne probes to establish a fluorophosphonate-based chemoproteomic resour...

Jaime A. Isern, M. G. Mediavilla, Exequiel O. J. Porta et al. · 0 citations

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