Single-domain antibody-conjugated lipid nanoparticles for selective mRNA delivery to CD4⁺ T cells and Brec1-mediated excision of HIV-1 proviral DNA
Approaches to curing HIV infection aim to eliminate the latent viral reservoir — long-lived, resting CD4⁺ T cells harboring integrated but transcriptionally silent proviral DNA — which persists despite effective antiretroviral therapy. The HIV-1 LTR-specific designer-recombinase Brec1 can precisely excise integrated pr...