J. Burnier

Nelfinavir Synergizes with Cisplatin and Promotes GSDME-Associated Lytic Cell Death in Platinum-Resistant Ovarian Cancer Cells

Background/Objectives: Platinum resistance limits the efficacy of ovarian cancer treatment and arises through multiple mechanisms, including enhanced DNA repair, activation of stress responses, and increased survival signaling. Nelfinavir (NFV), an HIV protease inhibitor with reported anti-tumor activity, is a candidat...

Cell-Free DNA Release Kinetics and Fragmentation Reflect Treatment Response and Resistance In Vitro

Background: Circulating tumor DNA (ctDNA) has emerged as a clinically valuable biomarker for cancer detection, treatment monitoring, and minimal residual disease assessment. Despite its growing clinical utility, the biological mechanisms governing ctDNA release remain incompletely understood. The objective of this stud...

Bottom-up engineering of EV-mimetic vesicles reveals selective protein loading and modulates cellular uptake and biodistribution

Impact of methodological variability on the prognostic performance of circulating tumor DNA in colorectal cancer: A systematic review and meta-analysis

CtDNA positivity is strongly associated with adverse survival outcomes across CRC stages and clinical settings, supporting its role as a clinically relevant biomarker and underscoring the need for standardized protocols and transparent reporting to facilitate comparison across studies and support reliable clinical impl...