Author

J. Bréa

2 papers indexed here

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Open access Oct 2026

Discovery of a Peripherally Directed CB1 Receptor Antagonist That Restores Insulin Signaling in Adipocytes

Piperazine-1-ium derivative 24a stands out as the first permanently charged CB1R antagonist, exhibiting nanomolar affinity and high CB1R/CB2R selectivity with a favorable physicochemical profile consistent with peripheral restriction and limited blood-brain barrier penetration.

J. Azuaje, Rubén Prieto-Díaz, Claudia Gioé-Gallo et al. · ACS Omega · 0 citations

Open access Sep 2026

The oxidative and carbonyl stress axis in anti-vascular endothelial growth factor-refractory neovascular age-related macular degeneration: Implications for therapeutic repurposing.

BACKGROUND AND PURPOSE Neovascular age-related macular degeneration is a leading cause of irreversible blindness, and approximately 25% of patients respond inadequately to intravitreal anti-VEGF therapy, representing a major unmet clinical need. We aimed to identify repurposable therapeutic alternatives by anchoring a...

D. Castro-Fernández, Antonio Cañizo-Outeiriño, A. L. Martínez et al. · European journal of medicina... · 0 citations