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Author

J. Bonanno

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Open access Aug 2026

The glycine N-methyltransferase amino-terminus regulates folate-dependent feedback inhibition and S-adenosylmethionine homeostasis

Maintenance of S-adenosylmethionine (SAM) homeostasis is essential for methylation of biomolecules, nucleotide and polyamine synthesis, and redox balance. While all methyltransferases consume SAM, only a subset of highly tissue-specific methyltransferases regulate methylation potential. Among them, glycine N-methyltran...

Isaac Kraz, Oi-Wei Mak, Subray Hegde et al. · 0 citations
Aug 2026

Mena EVH1 Interacts with PTP1B Via a Distributed Interface Without Regulating Enzymatic Activity.

The solution NMR structure of the unliganded Mena EVH1 domain is reported, which contains a conserved aromatic triad that forms the canonical polyproline-binding cleft that supports a model in which Mena functions as a scaffold to spatially organize PTP1B within EGFR signaling complexes.

Lanette LaComb, Sean M. Cahill, J. Bonanno et al. · 0 citations

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