Author

J. Bellmunt

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Open access Sep 2026

A tumor-cell MHC-II program is associated with checkpoint-blockade outcomes across stages of bladder cancer

Purpose A minority of patients with bladder cancer derive lasting benefit from immunotherapy, and current biomarkers capture only part of the biology. We evaluated whether tumor-cell MHC class II defines an immune state associated with outcome across disease stages and after PD-1/PD-L1 blockade. Experimental Design We...

J. Bellmunt, Ying-Tian Xie, M. Munoz et al. · bioRxiv · 0 citations

Review Open access Sep 2026

Somatic likelihood tiering: an interpretable post-calling triage protocol for tumor-only whole-exome variant review

SLT provides an auditable tumor-only WES review queue, not a substitute for matched-normal sequencing, independent orthogonal validation, or definitive somatic classification, and is the primary calibration frame.

Konrad Stawiski, S. Kamran, J. Perera-Bel et al. · Briefings in Bioinformatics · 0 citations