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Review Open access Oct 2026

Advances in disease management and treatment outcomes for obesity and knee osteoarthritis in primary care practice.

The lifetime risk of developing knee osteoarthritis (KOA) is approximately doubled in people with obesity compared with those without obesity. Many patients with KOA are treated by primary care physicians in the community setting. We performed a targeted literature search on PubMed to identify relevant literature descr...

Amanda E. Nelson, L. F. Callahan, T. Schnitzer et al. · 0 citations
Review Open access Oct 2026

Association of Frailty Status with Semi-Targeted Metabolomics and Untargeted Proteomics in Older Adults Referred for Physical Therapy in a Geriatric Clinic

Background: Older adults are vulnerable to frailty, but the biological mechanisms are unclear. Metabolomics and proteomics may help characterize the biological basis of frailty that can be used to target future interventions. Methods: This study is a cross-sectional analysis of baseline anthropometric, metabolomic, and...

Dakota J. Batchek, D. Lynch, Laura E. Herring et al. · 0 citations
#machine learning Preprint Oct 2026

Task-Centric Multimodal Learning for Cognitive Impairment Detection

Dementia affects millions of older adults worldwide, yet early detection remains difficult outside clinical settings. Traditional models primarily rely on text or voice-based responses, capturing only a limited view of human cognition despite the inherently multimodal nature of human expression. This work proposes a co...

Sankalp Vaish, Rishank Singh, Sumukh Veeramalla et al. · 0 citations
Review Open access Aug 2026

Risk of protein intake deficiency during treatment with GLP-1 and GIP/GLP-1 receptor agonists: considerations for secondary sarcopenia.

Sarcopenia, characterized by the age-related decline in muscle mass and strength, increases the risk of falls, fractures, disability, and mortality. Type 2 diabetes and obesity frequently coexist with sarcopenia, contributing to the growing clinical challenge of sarcopenic obesity. Incretin-based therapies, including g...

K. Prokopidis, Stefano Cacciatore, Stephen D. Anton et al. · 0 citations

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