Open access
Aug 2026
HIV-1 Nef Homodimerization as a Structural Mechanism for Kinase Activation and Small Molecule Inhibitor Action
It is found that mutations at dimer interface residues Leu112 and Phe121 abolish recombinant Nef protein dimerization while preserving the overall Nef fold, resulting in monomeric 1:1 complexes with Hck SH3 or SH3-SH2 domain proteins.
Catherine E. Thomas, J. Alvarado, Thomas E. Smithgall
· bioRxiv · 0 citations