Xylenes are ubiquitous environmental chemicals associated with central nervous system toxicity; however, their effects on cardiovascular disease are poorly understood. We tested the hypothesis that chronic m-xylene inhalation disrupts vascular homeostasis by inducing endothelial toxicity. Male C57BL/6 J mice were expos...
M. Malovichko, Samantha A. McFall, Breandon S. Taylor et al.· Toxicology and Applied Pharm...· 0 citations
It is demonstrated that repeated environmental heat stress induces coordinated neuroendocrine, vascular, immune, and metabolic adaptations characterized by activation of heat shock pathways, immune remodeling, and endothelial activation that precede cardiovascular dysfunction.
H. Husain, Samantha A. McFall, M. Malovichko et al.· The FASEB Journal· 0 citations
Allostatic load (AL) represents the cumulative physiological burden from activation of adaptive response systems. High AL, resulting from multisystemic dysregulation after chronic activation of response systems, is associated with chronic disease risk. Volatile organic compound (VOC) exposure may contribute to this dys...
Cameron K. Stopforth, Daniel W. Riggs, Rachel J. Keith et al.· Environmental Research· 0 citations
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