Ismail A. Abdelhamid

Recent advances in the synthesis, structural diversification, and biological evaluation of sulfamethoxazole derivatives

Sulfamethoxazole is a clinically important sulfonamide antibiotic that remains a valuable pharmacophore in medicinal chemistry due to its established antibacterial activity and structural versatility. However, the emergence of antimicrobial resistance and limitations related to solubility, pharmacokinetics, and safety...

Sub-molecular Alterations in Colorectal Cancer Cell Lines Following Therapy with mir497-5p Loaded Superparamagnetic Iron Oxide Nanoparticles (SPION): An ATR-FTIR Spectroscopy Study

Synthesis, Cytotoxicity, and Docking Studies of Novel Chalcones Incorporating 2‐(1 H ‐Indol‐1‐yl)‐ N ‐arylacetamide and Benzo[ d ]thiazole Moieties

Lead compound 7a significantly induced apoptosis and cell‐cycle arrest in MCF‐7 cells, as evidenced by increased apoptotic fraction, elevated sub‐G1 content, and accumulation of cells in the G2/M and S phases, and represents a promising multitarget anticancer lead for further optimization.