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Author

Ishrat Jabeen

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Open access Sep 2026

The protein-water H-bond network for bacterial response regulator REC domain activation

The bacterial response regulator (RR) superfamily is activated by aspartyl phosphorylation of the receiver (REC) domain for diverse functions. Crystal structures of the enteric CheY chemotaxis RRs (CheYes) have revealed water-residue hydrogen bonds (H-bonds) essential for activation. Here, we compared the H-bond networ...

Maham Hamid, Ishrat Jabeen, S. Chaudhary et al. · 0 citations
#protein folding Open access Oct 2026

Downstream mRNA Secondary Structure, Not Codon Elongation Supply, Coordinates Co-Translational Protein Folding Across the Human Ribosomal Exit Tunnel

While the overall effect size is modest, accounting for approximately 0.49% of local packing variance; its spatial specificity and consistency across independent structural metrics suggest that downstream mRNA stability acts as a localized mechanical brake during early chain compaction.

Muhammad Saad Ul Hassan, Ishrat Jabeen, Yusra Sajid Kiani · 0 citations

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