Isabelle Landrieu

Chaperone-inspired nanobodies enable pathway-selective control of Tau self-assembly

Selective control of pathogenic protein self-assembly remains a major challenge for intrinsically disordered amyloid-forming proteins such as Tau. Here we show that nanobodies originally raised against the chaperone S100B unexpectedly cross-react with Tau as potential pathway-selective modulators of Tau self-assembly...