Author

Isabella Caranzano

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Preprint Sep 2026

Predicting Mutational Signature Exposures from H&E Whole Slide Images: A Pan-Cancer Feasibility Study

Mutational signatures reveal cancer-driving processes with clinical relevance: MMR-deficient tumors respond better to immunotherapy, HRD tumors are sensitive to PARP inhibitors, and POLE-mutant tumors often have high mutation burdens influencing treatment response. Yet signature profiling remains limited by the cost, c...

Flavio Sartori, C. Rollo, Isabella Caranzano et al. · 0 citations

#artificial intelligence Preprint Sep 2026

Human mutation field reveals an equilibrium-like structure with irreversible circulation

A thermodynamic decomposition of the human mutation field is given: most mutation bias is organized by a local equilibrium-like energy landscape aligned with genome composition, while the residual circulation points to specific directional mutational mechanisms.

Isabella Caranzano, D. M. Busiello, Stefano Priorelli et al. · 0 citations