Neuroprotective effects of ROCK inhibition on hippocampal energy metabolism in a rat model of metabolic syndrome
Objective(s): Metabolic syndrome (MS) is associated with insulin resistance, hyperglycemia, and dyslipidemia, leading to impaired neuronal energy metabolism and hippocampal dysfunction. Rho-associated kinase (ROCK) has been implicated in metabolic and neuroinflammatory dysregulation; however, its role in MS-induced hip...