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Irena Manolova

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Open access Aug 2026

Impact of IL6 and IL18 Promoter Polymorphisms on Circulating Cytokine Levels, Gene Expression, and Susceptibility to Rheumatoid Arthritis

Our study examined the impact of IL6 −174 G/C (rs1800795) and IL18 −607 C/A (rs1946518) promoter polymorphisms on susceptibility to rheumatoid arthritis (RA) and protein/mRNA levels. RA patients had significantly higher serum IL-6 and IL-18 levels than controls; healthy men had higher IL-18 than women (p < 0.001). Conv...

V. Vasileva, G. Vasilev, M. Ivanova et al. · 0 citations

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