Ipsita Biswas

Topoisomerase-mediated resolution of negative DNA supercoiling sustains human transcription and gene activation

Transcription generates DNA supercoiling that can influence gene expression, but how transcription-associated supercoiling shapes RNA polymerase II (RNAPII) dynamics in human cells remain poorly understood. Here, we show that topoisomerase-mediated resolution of negative DNA supercoiling is required for productive tran...