Cyclooxygenase-2 as a Prognostic Biomarker in Colorectal Cancer: Immunohistochemical Assessment and Correlation with Clinicopathological Parameters and Disease-free Survival in a Kashmiri Cohort
Colorectal cancer (CRC) is a major global disease with an increasing incidence in South Asia, especially the Kashmir valley. Cyclooxygenase-2 (COX-2), an inducible enzyme that converts arachidonic acid to prostaglandins, promotes tumorigenesis via angiogenesis, apoptosis resistance, invasion, and immune evasion....