The Role of Liquid Biopsy in Detecting KRAS, NRAS, and BRAF Mutations in Metastatic Colorectal Cancer: A Systematic Review
Introduction: Metastatic colorectal cancer (mCRC) is a leading cause of cancer-related mortality, with molecular profiling of KRAS, NRAS, and BRAF mutations essential for guiding first-line therapy. Although liquid biopsy using circulating tumor DNA (ctDNA) offers a promising non-invasive alternative to tissue biopsy,...