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Ilya S. Dovydenko

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Review Open access Oct 2026

Synthetic Errors During Solid-Phase Phosphoramidite Synthesis of Oligonucleotides

While solid-phase phosphoramidite chemistry remains the gold standard for nucleic acid synthesis, the rigorous purity requirements of modern therapeutic oligonucleotides demand a much tighter control over side reactions. This review critically examines the underlying mechanisms of impurity formation during chain assemb...

Yuliya V. Sherstyuk, Ilya S. Dovydenko · 0 citations

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