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Ildefonso Cases

2 papers indexed here

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Open access Sep 2026

USP-48 enables insulin-mediated longevity and modulates the mitochondrial stress response.

The mitochondrial prohibitin (PHB) complex is essential for mitochondrial homeostasis, yet its depletion produces opposite effects on lifespan: shortening it in wild-type C. elegans but extending it in insulin/IGF-1 receptor daf-2 mutants, which show an attenuated mitochondrial unfolded protein response (UPRmt). To ide...

Sergio Gordillo-García, Jesus Fernandez-Abascal, Blanca Hernando-Rodríguez et al. · 0 citations
#small language model Open access Sep 2026

Protein Language Model Embeddings Recover Evolutionary and Functional Organization Across the Ras Superfamily.

Analysis of a curated Ras superfamily dataset indicates that protein language model embeddings provide an effective alignment-free representation of Ras family and subfamily organization, and can highlight candidate sequence regions associated with functional specialization from sequence alone.

Ildefonso Cases, A. Valencia, Ana M. Rojas · 0 citations

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