Idoia Quintana Urzainqui

16p11.2 microdeletion enhances gene expression variability between human IPSC-derived forebrain interneuron progenitor cells in culture

Study of human-induced pluripotent stem cell derived ventral telencephalic interneuron progenitors in two-dimensional culture finds that transcript level variation is significantly greater between 16p11.2 heterozygous progenitors than their isogenic wild type counterparts, suggesting that the 16p11.2 locus itself has a genome-wide property in stabilizing transcription between cells.