Jul 2026
Disrupted WWOX-MYC interplay impairs neurogenesis in human brain organoids.
A model in which WWOX mutations impair neurogenesis via RG through cell-type specific dysregulation of the MYC and Wnt signaling pathways is proposed, highlighting potential therapeutic strategies for WWOX-related disorders and open avenues for interventions targeting these key molecular pathways.
Daniel J. Steinberg, A. Zonca, Dania Abdellatif et al.
· Brain : a journal of neurolo... · 0 citations