Author

Ichiro Hiratani

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Open access Sep 2026

Repeat element–anchored enhancer–promoter interactions (REEPIs) shape the regulatory landscape of hormone-resistant breast cancer

Repeat elements (REs) comprise over half of the human genome and are increasingly recognized as regulatory components, yet their role in therapy resistance remains unclear. Here, we integrate CAGE and RADICL-seq to map regulatory elements and RNA–chromatin interactions in estrogen receptor– positive breast cancer cells...

Xu-Feng Shu, Sheng-Lian Ni, M. Murata et al. · bioRxiv · 0 citations

Open access Sep 2026

Single-cell mapping of chromosome breaks identifies multiple fragile site classes with distinct DNA replication timing landscapes

Common fragile sites (CFSs) are genomic regions susceptible to chromosome breaks. However, because they were identified using cell populations, low-frequency fragile sites (non-CFSs) could have been overlooked. Here we perform single-cell genome-wide mapping and classification of aphidicolin-induced chromosome breaks....

Jothivanan Elumalai, Ichiro Hiratani · Nature Communications · 0 citations