Ian Asaf Muñoz-Granados

Endogenous phosphatidylinositol 4,5-bisphosphate facilitates activation of heterologously expressed TMEM16A via functionally coupled binding sites.

The Ca²⁺-activated Cl⁻ channel TMEM16A translates cytosolic Ca²⁺ signals into transmembrane Cl⁻ fluxes, supporting essential physiological functions across diverse tissues. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a phosphoinositide enriched in the inner leaflet of the plasma membrane, has emerged as a key re...