Probing the interaction between the WDR41 7CD loop of the C9ORF72 complex and purified PQLC2
The lysosomal cationic amino acid transceptor PQLC2 integrates transport with receptor-like signaling roles by recruiting the C9ORF72/SMCR8/WDR41 (CSW) complex in response to cellular cationic amino acid depletion. CSW recruitment depends on the interaction of PQLC2 with a disordered loop (7CD loop) extending from the...