ABSTRACT Intranasal COVID-19 vaccines with the ability to induce broad and durable mucosal and systemic immunity would be useful as stand-alone vaccines or in combination with injectable vaccines. We evaluated in hamsters the breadth of immunity and durability of protection elicited by co-administration of two live-att...
Hong-Su Park, Yumiko Matsuoka, Celia Santos et al.· Journal of Virology· 0 citations
In the hamster model, intranasal immunization with live-attenuated B/HPIV3 expressing SARS-CoV-2 S can provide durable protection for several months, and combining two antigenically distinct B/HPIV3 S-expressing vectors substantially broadens the antibody response.
Hong-Su Park, Yumiko Matsuoka, Celia Santos et al.· bioRxiv· 0 citations
ABSTRACT Intranasal COVID-19 vaccines with the ability to induce broad and durable mucosal and systemic immunity would be useful as stand-alone vaccines or in combination with injectable vaccines. We evaluated in hamsters the breadth of immunity and durability of protection elicited by co-administration of two live-att...
Hong-Su Park, Yumiko Matsuoka, Celia Santos et al.· Journal of Virology· 0 citations
Hundreds of recall and de novo neutralizing monoclonal antibodies are isolated and characterized after sequential exposures to SARS-CoV-2 variants in ancestral-imprinted humans to reveal the distinct contributions of recall and de novo antibodies to a balanced immune response and underscore the benefit of updated boost...
T. Johnston, Shuk-Hang Li, M. Painter et al.· Nature Immunology· 2 citations
The dependence of effective variant-specific antibodies on vaccination history is shown which may explain birth-year influence on differential susceptibility to SARS-CoV-2 variants XFG and BA.3.3.2, and it is suggested that vaccination regimens in children should prioritize neutralization breadth.
T. Johnston, Rahul Subramanian, Wakinyan Benhamou et al.· bioRxiv· 0 citations
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