Author

I. Skoog

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Open access Oct 2026

Alzheimer's disease genetics converges on microglial and neuronal dysregulation.

Alzheimer's disease (AD) is the most common cause of dementia, with global case numbers projected to reach 153 million in 20501. AD is highly heritable, with twin-based heritability estimates of 60-80%2. Although 1,200 causal loci are predicted to exist for AD3, approximately 80 loci have been associated with AD in two...

E. Uffelmann, D. Wightman, S. Bahrami et al. · Nature · 0 citations

Open access Dec 2026

Reproductive Lifespan and Hormonal Therapy in Relation to Later-Life Neurovascular Health in Community-Dwelling Older Women.

BACKGROUND AND OBJECTIVES Women are disproportionately affected by Alzheimer disease (AD), a vulnerability that may relate to estrogen fluctuations across the lifespan. Estrogen has neuroprotective and vasoprotective effects, suggesting that lifetime estrogen exposure may influence both AD-related neurodegeneration and...

Giulia Lorenzon, Gemma García-Lluch, G. Coughlan et al. · Neurology · 0 citations