Author

I. Silva

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Open access Oct 2026

Robust Alpha Spending for Unstable Data

Sequential hypothesis testing has been used in randomized clinical trials and in monitoring adverse events after vaccination. Typically, the presumption is that all data that have been previously used in the sequential analysis remain the same, and only new data are added. We call this the “anchoring” assumption. In pr...

I. Silva, J. Maro · Statistics in Medicine · 0 citations