I. Rosenhek‐Goldian

Long-lasting extracellular matrix modifications reshape intestinal stem cell fate and promote chronic inflammation.

Tissue regeneration is viewed as a return to homeostasis, but whether the extracellular matrix (ECM) reverts during recovery from gut inflammation is unclear. Using temporal multi-omics, biomechanical profiling, and spatial fate mapping in colitis models, we showed that colonic ECM underwent lasting pathological reprog...