Author

Ioannis Papantoniou

2 papers indexed here

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Open access Sep 2026

Endothelialized callus organoids drive rapid regeneration of critical-size segmental long bone defects.

Large bone defects remain a major clinical challenge, as current treatments cannot effectively regenerate them and fail to restore functionality. To recapitulate the cellular complexity of the early fracture callus, we engineered human endothelialized callus organoids (hECOs) by co-culturing periosteum-derived skeletal...

H. Svitina, J. Bai, T. Martens et al. · Cell Stem Cell · 0 citations

Open access Aug 2026

Scalable 4D biofabrication process for the manufacture of scaffold-free bone-forming callus implants.

Critical-size long bone defects remain a major clinical challenge, with treatments such as autografts or distraction osteogenesis causing donor-site morbidity, infection, or failure to restore complex bone architecture. Tissue-engineered implants that recapitulate native fracture healing provide a promising solution. H...

Andreas Dimopoulos, Konstantinos Ioannidis, Nikolaos S. Giakoumakis et al. · Trends in Biotechnology · 0 citations