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It is demonstrated that while local ancestry inference recovers biologically meaningful signals in ancient genomes, results can be sensitive to the methods used for inference, particularly in complex regions like the HLA.
Admixed individuals have been understudied in medical research largely due to their complex genetic ancestries. However, the consideration of admixture can identify ancestry-enriched genetic associations, delineating genetic underpinnings of cross-population phenotypic variation. Here, we performed admixture mapping in...
The current state of knowledge about the impact of selection on human genomic diversity is reviewed and conceptual advances in the understanding of human evolution over the past 10,000 years are highlighted.
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