``Single-cell and spatial atlases describe the healthy and diseased liver at high resolution, including lobular hepatocyte zonation, fibrotic macrophage-stellate niches, cholangiocyte reactions, immune remodeling, and hepatocellular carcinoma ecosystems. These maps show where cell states occur but do not, by themselves...
Youngseok Choi, I. Koh, Murim Choi et al.· Clinical and Molecular Hepat...· 0 citations
Genotype-dependent neurodevelopmental phenotypes associated with reduced USP15 dosage are characterized and a human neural framework for investigating ASD-relevant developmental mechanisms in the context of a rare ubiquitin-pathway variant is provided.
Tae-Hwan Park, I. Koh, S. Sung et al.· 0 citations
This framework integrates predicted perturbation effects with genomic evidence to support autism candidate prioritization and identifies a telencephalic neuron-specific model best preserving autism-relevant perturbation structure.
I. Koh, E. Chang, Youngseok Choi et al.· bioRxiv· 0 citations
De novo variants in the ubiquitin-proteasome pathway are linked to autism spectrum disorder (ASD), yet their functional impact on neurodevelopment remains poorly understood. We investigated USP15, a deubiquitinating enzyme with rare damaging variants identified in individuals with ASD, using isogenic human iPSC-derived...
Tae-Hwan Park, I. Koh, Seoyoung Sung et al.· Molecules and Cells· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
