Author

I. Kelters

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Open access Sep 2026

PKP2 orchestrates OXPHOS expression in cardiomyocytes via a PGC1α-dependent mechanism

Abstract Aims Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease in which most patients carry (likely) pathogenic variants in desmosomal genes, most commonly in plakophilin-2 (PKP2). While the genetic causes are well described, the molecular mechanisms driving disease progression—particularly in respon...

Su-Ji Han, Daphne van den Berg, H. de Ruiter et al. · Cardiovascular Research · 0 citations

When the Time is Right

Heart failure is a chronic, progressive condition and a leading cause of morbidity and mortality worldwide. Despite advances in treatment, prevention remains essential, as cardiac damage becomes increasingly difficult to reverse once dysfunction and remodelling have developed. This thesis explores two factors that may...

I. Kelters · 0 citations