Bipolar disorder (BD) is highly heritable, yet the contribution of rare coding variation remains incompletely characterized. We analyzed sequencing data from 64,435 individuals with BD and 168,101 controls spanning multiple ancestries and 22 countries, representing the largest and most global sequencing resource with a...
C. Liao, R. Ye, J. Sealock et al.· medRxiv· 0 citations
ABSTRACT Background While growing evidence implicates sleep‐wake and circadian rhythm disturbances (SCRDs) in the onset and course of mood and psychotic disorders, longitudinal studies using objective measures are limited. This clinical cohort study examined whether actigraphy‐derived SCRDs (sleep duration, timing, and...
J. Carpenter, J. Crouse, M. Varidel et al.· Bipolar Disorders· 0 citations
Bipolar disorder’s genetic architecture appears hierarchical—a general liability resolving into dimensions of course and comorbidity, beyond subtypes, beyond subtypes.
Tracey van der Veen, M. Tesfaye, J. M. K. Yang et al.· Research Square· 0 citations
Sleep quality and affective symptoms exhibit a feedback loop, whereby poor sleep quality influences affective symptoms over consecutive days, which supports interventions that target sustained improvement in sleep and possibly circadian regulation to improve affective symptoms.
M. Varidel, L. Borgnolo, V. An et al.· medRxiv· 0 citations
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