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Author

I. Fernandes

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Review Open access Aug 2026

Exclusion of patients with brain metastases from early-phase systemic therapy trials: a cross-sectional analysis of eligibility criteria

Patients with brain metastases (BrM) are frequently excluded from early-phase clinical trials, limiting evaluation of central nervous system (CNS) efficacy of novel therapies. We aimed to determine the proportion of phase I systemic therapy trials for patients with metastatic solid tumours that permit enrolment of pati...

C. Zatzman, I. Fernandes, I. Kojundzic et al. · 0 citations
Jul 2026

Clinicopathological factors associated with brain metastases development among breast cancer patients receiving neoadjuvant chemotherapy

Among patients treated with NAC for early-stage BC, residual nodal disease, inflammatory BC, and HER2+ or triple-negative subtype are associated with a higher risk of BrM development and whether BrM screening is warranted among patients with these high-risk features warrants evaluation.

Jie Zhu, I. Fernandes, Júlia Belone Lopes et al. · 0 citations

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