Author

I. B. Huang

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Open access Sep 2026

MAP2-mediated integrin dysregulation reprograms cancer cell plasticity in hepatocellular carcinoma

Targeting tumor cell plasticity is central to overcome drug resistance and metastasis. Through lineage-tracing and lineage-ablation studies, our team has previously shown hepatocellular carcinoma (HCC) cells marked by CD133 to represent a functional subset displaying dedifferentiated status with stemness traits, yet th...

U. Lou, Tin-Lok Wong, I. B. Huang et al. · Nature Communications · 0 citations

Open access Aug 2026

p38β-mediated BiP phosphorylation drives stemness and chemoresistance by suppressing UPR activation in hepatocellular carcinoma

It is discovered that p38β/MAPK11 phosphorylation of BiP promotes stemness and chemoresistance in HCC, revealing a targetable p38β–BiP axis in HCC.

Liang Xu, I. B. Huang, Minghe Zhang et al. · Nature Communications · 0 citations