Author

I. Ahel

3 papers indexed here

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Open access Oct 2026

Identification of Novel Enzymes Regulating ADP-Ribosylation of Uracil and Thymine in Nucleic Acids.

ADP-ribosylation (ADPr) is a conserved modification that regulates a wide range of cellular processes. Although proteins are the best-characterized substrates of ADPr, recent studies have demonstrated that nucleic acids can also be modified. However, the enzymes responsible for installing and removing nucleic acid ADPr...

Yang Lu, W. Deeksha, Kang Zhu et al. · Journal of Biological Chemis... · 0 citations

Jul 2026

Deciphering the Specificity of Reversible DNA-Phosphate ADP-Ribosylation via the Precise Synthesis and Enzymatic Profiling of Nucleotide-Phospho-ADP-Ribosyl Probes.

The stereoselective synthesis of deoxynucleotide-phospho-ADPr (dN-P-ADPr) probes are reported, representing native fragments of terminal DNA-ADPr, showing that these enzymes exhibit an absolute preference for the native-like α-anomer, independent of the identity of the adjacent DNA nucleobase, suggesting that substrate...

Lingxiao Liu, Yang Lu, Zongxing Yu et al. · Journal of the American Chem... · 0 citations

Open access Jul 2026

X‑ray Crystallography-Guided Design and Synthesis of Cyclopentyl Heteroaryl Carboxylic Acid-Based Inhibitors of the SARS-CoV‑2 Nsp3 Macrodomain (Mac1)

Mac1 is a conserved macrodomain enzyme in the nonstructural protein 3 (Nsp3) of SARS-CoV-2 and is part of the viral replication machinery. Mac1 is a target for small-molecule inhibitors that could ultimately enable new COVID-19 therapeutics to be developed. Here, we report the structure-guided design, synthesis, and Ma...

Xinyu Wang, William T W Butler, James R Donald et al. · Journal of Medicinal Chemist... · 0 citations