Glycans constitute the first molecular landscape encountered by viruses during infection and play fundamental roles in viral attachment, host adaptation, tissue tropism, and immune evasion. Far from being passive components of the cell surface, host glycans actively regulate virus–host interactions by functioning as at...
Cristina Fernández Pérez, María Emilia Cuervo, I. A. Bermejo et al.· RSC Chemical Biology· 0 citations
Cell surface receptors are traditionally conceptualized as discrete molecular entities whose functional diversity arises primarily from gene expression and protein sequence variation. However, this view overlooks the extensive heterogeneity generated by post‐translational modifications, particularly glycosylation, whic...
María Payá-García, José Manuel Rojas-Marcos, I. A. Bermejo et al.· ChemBioChem· 0 citations
Post-translational modifications critically regulate extracellular molecular recognition, yet their roles in intrinsically disordered proteins remain poorly defined. Here, we integrate glycoproteomics, NMR, and cellular assays to reveal how glycosylation shapes the interaction network of osteopontin (OPN), a highly g...
I. A. Bermejo, D. del Balzo, M. Azkargorta et al.· JACS Au· 0 citations
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