Mechanistic insights into PFAS-induced toxicity: from lipid membrane perturbation to ion channel and transporter dysregulation.
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants associated with a wide range of adverse health outcomes, including metabolic, developmental, and neurodevelopmental disorders. Recent evidence suggests that PFAS can act as membrane-active compounds, directly interacting with lipid bil...