Author

Hyun Jin Kim

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Aug 2026

Polyaspartamide-Mediated Messenger RNA Delivery Enables Efficient Ex Vivo Engineering of Chimeric Antigen Receptor Natural Killer Cells via Enhanced Cellular Internalization.

Engineered natural killer (NK) cells expressing chimeric antigen receptor (CAR) represent a promising alternative to CAR T-cell therapy due to their allogeneic potential. However, current CAR NK cell production relies on lentiviral or retroviral transduction to achieve stable CAR expression, requiring complex, multiste...

Ha Yeon Park, Seon-Jeong Kim, Kyuree Kim et al. · ACS Applied Materials and In... · 0 citations

Sep 2026

Programmable ternary polyplexes redirect systemic mRNA delivery to the spleen for in vivo CAR engineering.

In vivo engineering of chimeric antigen receptor (CAR) immune cells has emerged as a promising alternative to ex vivo cell manufacturing, but its clinical translation remains limited by the lack of delivery systems capable of selective programming immune cells within lymphoid organs. Here we report a rationally enginee...

Sung Been Lim, Seon-Jeong Kim, Jun-Su An et al. · Journal of Controlled Releas... · 0 citations

#protein folding Open access Sep 2026

Harnessing the Folding of Antitumor Peptides for Controlled Carrier-Free Drug Delivery.

An antitumor peptide-based delivery platform in which both termini of a stapled p53 α-helix are linked via a disulfide bond, thereby repurposing nonpolar residues originally involved in target protein (hDM2) binding as a hydrophobic block that drives co-assembly with doxorubicin.

Jae Yun Lee, Moo Chang Park, Sung-Chan Choi et al. · Small · 0 citations