Hyun Jeong Lee

Discovery, identification of tricyclic sesquiterpene avermitilol synthase, and its heterologous production in plasmid-free Corynebacterium glutamicum.

Tricyclic sesquiterpenes are bioactive natural products with broad applications in pharmaceuticals, fragrances, and sustainable aviation biofuels. However, the repertoire of characterized tricyclic sesquiterpene synthases (tSTSs) remains limited. To systematically expand this enzyme class, we developed a multi-step bio...