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Author

Hyerim Jung

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Open access Sep 2026

Sensitizing tumor response to topoisomerase I antibody-drug conjugate by selective CDK7 inhibition

This study investigates the transcriptional impact of Q901, a highly selective cyclin-dependent kinase 7 (CDK7) inhibitor in clinical development. Q901 primarily disrupted MYC and E2F-dependent transcription programs, down-regulating cell cycle control and DNA damage repair pathways. CDK7 binding at the promoter-proxim...

Hyerim Jung, Yoonji Lee, Donghoon Yu et al. · 0 citations

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