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Hyeon-Ok Jin

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Open access Oct 2026

Metformin Inhibits Ferroptotic Cell Death by Suppressing Cysteine Deprivation‐Induced Mitochondrial Dysfunction

Ferroptosis, an iron‐dependent form of regulated cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic strategy for cancer. Metformin, a widely used biguanide antidiabetic drug, has recently been reported to induce ferroptosis and exert anticancer effects in various malignancies. How...

S. Jang, Selim Kim, Gyeongmi Kim et al. · 0 citations
Open access Sep 2026

Lapatinib suppresses cysteine deprivation-induced ferroptotic cell death by modulating mitochondrial function

Lapatinib exerts context-dependent effects, suppressing cysteine deprivation- induced ferroptosis despite inducing a mild ferroptotic phenotype when used alone, and attenuates cysteine deprivation-induced mitochondrial metabolic activation.

Gyeongmi Kim, S. Jang, Do-Gyeong Kim et al. · 0 citations
Open access Sep 2026

Tubacin induces TFEB-dependent ferritinophagy independently of HDAC6 and sensitizes cancer cells to ferroptosis under GSH-GPX4 axis disruption.

These findings identify TFEB-driven lysosomal activation and ferritinophagy as a critical determinant of ferroptotic sensitivity under redox imbalance and suggest that pharmacological modulation of TFEB-lysosomal function by tubacin may represent a potential strategy for enhancing ferroptosis-based cancer therapy.

Gyeongmi Kim, S. Jang, Do-Gyeong Kim et al. · 0 citations

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