Open access
Mar 2025
Nucleosome Engagement Regulates RORγt Structure and Dynamics
RORγt is a key transcriptional regulator that supports protective pathogen clearance but also drives autoimmune disorders. Genetic studies have identified RORγt mutations that selectively protect from autoimmunity without compromising host defense. Herein, we describe the molecular principles governing how RORγt select...
Timothy S. Strutzenberg, Xian-Du Li, Matthew D. Mann et al.
· bioRxiv · 0 citations