Open access
Aug 2026
Dual-mode SOX2 regulation by miR-150 via mRNA suppression and autophagy controls stem cell fate
A role for miR-150 deficiency in biasing ectoderm–mesoderm lineage specification in hPSCs is defined and SOX2 is identified as a key downstream node regulated primarily through altered mRNA stability, with additional involvement of an autophagy-associated pathway.
Xing Zhen, Hyebin Koh, Dong-Seok Lee et al.
· Signal Transduction and Targ... · 0 citations