Modulatory Effects of IL-24 on Autophagy and Apoptosis in Large Cell Lung Carcinoma
It is validated that IL-24 exerts potent anti-cancer activity in primary LCLC by triggering excessive, toxic autophagy that drives past a cytoprotective survival threshold, successfully engaging the ATG4/ATG5 molecular switch to orchestrate a fatal transition into the intrinsic mitochondrial apoptotic pathway.