Author

Hussein Sabit

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Open access Oct 2026

Circulating Immune-Related Biomarkers in Egyptian Women with Early Breast Cancer: An Exploratory Case–Control Study Across IHC-Defined Clinicopathological Subgroups

Background: Breast cancer (BC) progression depends on immune dysregulation and complex interactions between tumor cells and host immune components. Soluble immune checkpoints, growth factors, chemokines, and cytokines are promising circulating biomarkers; however, their clinical relevance across IHC-defined clinicopath...

Rania Zaki, Auhood Nassar, R. A. Al Najar et al. · Cells · 0 citations

Review Open access Sep 2026

Bioactive compounds from Perilla frutescens modulate multiple cell death pathways and signaling networks in cancer therapy

Perilla frutescens, an edible medicinal plant from East Asia, produces diverse bioactive phytochemicals with anticancer activity, including perillaldehyde (PAH), rosmarinic acid (RA), luteolin, apigenin, and alpha-linolenic acid (ALA). These compounds exert multi-target anticancer effects through apoptosis, autophagy,...

Hai Xu, Jing-Yi Liu, Hui-Kun Wu et al. · Frontiers in Pharmacology · 0 citations

Open access Aug 2026

Targeted Folate-Chitosan Nanoformulations of Quercetin and Coriandrum sativum Reprogram Breast Cancer Hallmarks by Silencing Stemness, Cell Cycle, Angiogenic, and Metastatic Networks

Folate-functionalized chitosan nano-formulations significantly enhanced the anticancer efficacy of quercetin and Coriandrum sativum seed extract through improved targeted delivery, potent antiproliferative, anti-angiogenic, and pro-apoptotic activities, together with favorable modulation of multiple molecular pathways...

Nariman Nabil, Hussein Sabit, J. Almulhim et al. · Pharmaceuticals · 0 citations

Review Open access Aug 2026

Cancer-associated adipocytes: metabolic reprogramming, crosstalk and therapeutic implications in tumor progression

This review synthesizes how CAAs and adipose dynamics drive oncogenesis, progression and therapeutic failure and highlights actionable nodes within the adipose–tumor axis for precision oncology.

Jin-Min Shi, S. Abdel-Ghany, Mariam M Abdelfattah et al. · Signal Transduction and Targ... · 1 citation

Review Open access Sep 2026

Epigenetic Plasticity in Triple-Negative Breast Cancer: Mechanisms of Therapy Resistance, Biomarkers, and Therapeutic Vulnerabilities

Overall, epigenetic plasticity represents both a major driver of TNBC resistance and a therapeutically exploitable vulnerability, provided those future strategies account for tumor heterogeneity, adaptive cell-state transitions, biomarker-guided patient selection, and combination-based treatment design.

A. Alaa, Salma A. B. El-Din, Mohannad A. Farrag et al. · Biomedicines · 0 citations