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Author

Huiyong Ma

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Open access Aug 2026

Discovery of Highly Potent G Protein-Biased Bisamide Kappa Opioid Receptor Agonists.

Through a structure-activity relationship (SAR) study of a bisamide-containing lead series, a group of KOR agonists with subnanomolar potency in G protein signaling and several with bias for G protein activation over βarrestin2 recruitment are generated.

Kimberly S. Taylor, Kerri M. Czekner, Aubrie A. Harland et al. · 0 citations
Review Open access 2026

Therapeutic oligonucleotides revisited: Focus on siRNA and antisense technologies

This review first provides a concise overview of the mechanistic principles underlying oligonucleotide function and commonly employed chemical modification techniques, and highlights recent advancements in receptor-mediated delivery systems for extrahepatic targeting, and dual-targeting oligonucleotide engagement strat...

Liuhai Chen, Jiahao Xu, Jin Li et al. · 2 citations

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