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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Huichong Liu

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Jul 2026

Directed Evolution of Nonheme Fe Enzymes for Enantioselective and Regiodivergent 1,3- and 1,4-Nitrogen Migration: Biocatalytic Asymmetric Synthesis of Noncanonical α- and β-Amino Acids.

Two complementary nitrogen migratases were developed that enabled biocatalyst-controlled 1,3- and 1,4-nitrogen migration with excellent regioselectivity and exhibited similar kinetic isotope effects for both 1,5- and 1,6-HAT pathways, suggesting that enzyme engineering controls regio- and enantioselectivity but does no...

Huichong Liu, Liu-Peng Zhao, Shijia Li et al. · 0 citations

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